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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">CCL2</span></h1>
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<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="de" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="de" dir="ltr"><table class="wikitable hintergrundfarbe-basis infobox float-right" id="Vorlage_Infobox_Protein_CCL2" style="font-size:90%; margin-top:0; width:350px;" summary="Infobox Protein">

<tbody><tr>
<th colspan="3" style="background:#90EE90; color:#202122;">CCL2
</th></tr>
<tr style="text-align:center;">
<td colspan="3"><span typeof="mw:File"></span>
</td></tr>
<tr>
<td colspan="3" class="hintergrundfarbe1" style="text-align:center; font-size:smaller; font-weight:bold;">nach <a href="Protein_Data_Bank" title="Protein Data Bank">PDB</a>&nbsp;<a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1DOK">1DOK</a>
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<tr>
<td>Andere Namen
</td>
<td colspan="2">
<ul><li>Chemokine (C-C Motif) Ligand 2</li>
<li>Monocyte Chemotactic And Activating Factor</li>
<li>Monocyte Chemotactic Protein 1</li>
<li>Monocyte Secretory Protein JE</li>
<li>SCYA2</li>
<li>MCAF</li>
<li>MCP1</li>
<li>Small Inducible Cytokine A2 (Monocyte Chemotactic Protein 1, Homologous To Mouse Sig-Je)</li>
<li>Monocyte Chemoattractant Protein-1</li>
<li>HSMCR30</li>
<li>GDCF-2</li>
<li>SMC-CF</li></ul>
</td></tr>
<tr>
<td colspan="3" class="hintergrundfarbe1" style="font-size:smaller;">
<p>Vorhandene Strukturdaten: <span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1DOK">1DOK</a></span>, <span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1DOL">1DOL</a></span>, <span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1DOM">1DOM</a></span>, <span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1DON">1DON</a></span>, <span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1MCA">1MCA</a></span>, <span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1ML0">1ML0</a></span>
</p>
</td></tr>
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<th colspan="3" style="background:#90EE90; color:#202122;;">Eigenschaften des menschlichen Proteins
</th></tr>
<tr>
<td><a href="Molare_Masse" title="Molare Masse">Masse</a>/Länge <a href="Prim%C3%A4rstruktur" title="Primärstruktur">Primärstruktur</a>
</td>
<td colspan="2" style="text-align:center;">99 Aminosäuren, 11025 Da
</td></tr>








<tr>
<th colspan="3" style="background:#90EE90; color:#202122;">Bezeichner
</th></tr>

<tr>
<td>Externe IDs
</td>
<td colspan="2" class="">
<ul><li><a href="GeneCards" title="GeneCards">GeneCards</a>:&nbsp;<a rel="nofollow" class="external text" href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=CCL2">CCL2</a></li>
<li><a href="Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a>:&nbsp;<a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/omim/158105">158105</a></li>
<li><a href="UniProt" title="UniProt">UniProt</a> <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/P13500">P13500</a></li></ul>
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<tr>
<th colspan="3" style="background:#90EE90; color:#202122;">Vorkommen
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<tr>
<td style="background:#C3FDB8; color:#202122;">Homologie-Familie
</td>
<td colspan="2" style="text-align:center;"><a rel="nofollow" class="external text" href="http://hogenom.univ-lyon1.fr/query_sequence?seq=P13500">Hovergen</a>
</td></tr>


<tr>
<td colspan="3" style="background:#90EE90; color:#202122; text-align:center;"><a href="Homologie_(Genetik)#Homologie_zwischen_verdoppelten_oder_fremden_Genen" title="Homologie (Genetik)">Orthologe</a>
</td></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;">
</td>
<td style="background:#C3FDB8; color:#202122; text-align:center;">Mensch
</td>
<td style="background:#C3FDB8; color:#202122; text-align:center;">Hausmaus
</td></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;"><a href="Entrez_Gene" title="Entrez Gene">Entrez</a>
</td>
<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&amp;cmd=retrieve&amp;dopt=default&amp;list_uids=6347&amp;rn=1">6347</a></span>
</td>
<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&amp;cmd=retrieve&amp;dopt=default&amp;list_uids=20293&amp;rn=1">20293</a></span>
</td></tr>

<tr>
<td style="background:#C3FDB8; color:#202122;"><a href="UniProt" title="UniProt">UniProt</a>
</td>
<td><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/P13500">P13500</a>
</td>
<td><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/Q62401">Q62401</a>
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<tr>
<td style="background:#C3FDB8; color:#202122;"><a href="PubMed" title="PubMed">PubMed</a>-Suche
</td>
<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&amp;cmd=Link&amp;LinkName=gene_pubmed&amp;from_uid=6347">6347</a></span>
</td>
<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&amp;cmd=Link&amp;LinkName=gene_pubmed&amp;from_uid=20293">20293</a></span>
<p><span class="editoronly" style="display:none;"></span>
</p>
</td></tr></tbody></table><p><span class="editoronly" style="display:none;"></span>
</p><p><b>CCL2</b> (<span style="font-style:normal;font-weight:normal"><a href="Englische_Sprache" title="Englische Sprache">englisch</a></span> <span lang="en-Latn" style="font-style:italic">CC-chemokine ligand 2</span> ‚CC-Chemokinligand 2‘) ist ein <a href="Zytokin" title="Zytokin">Zytokin</a> aus der Familie der CC-<a href="Chemokin" title="Chemokin">Chemokine</a>. Synonyme für das CCL2 sind <i>monocyte chemotactic protein 1</i> (MCP1) und <i>small inducible cytokine A2</i>.
</p>
<div class="mw-heading mw-heading2"><h2 id="Eigenschaften">Eigenschaften</h2></div>
<p>CCL2 wird an Orten einer <a href="Entz%C3%BCndung" title="Entzündung">Entzündung</a> von <a href="Monozyt" title="Monozyt">Monozyten</a>, <a href="T-Ged%C3%A4chtniszelle" title="T-Gedächtniszelle">T-Gedächtniszellen</a> und <a href="Dendritische_Zelle" title="Dendritische Zelle">dendritische Zellen</a> gebildet, <a href="Sekretion" title="Sekretion">sezerniert</a>, an <a href="Proteoglykan" class="mw-redirect" title="Proteoglykan">Proteoglykane</a> von <a href="Endothelzellen" class="mw-redirect" title="Endothelzellen">Endothelzellen</a> gebunden, durch die <a href="Matrix-Metalloproteasen" title="Matrix-Metalloproteasen">Matrix-Metalloprotease</a> 12 (<i>MMP-12</i>) <a href="Proteolyse" title="Proteolyse">proteolytisch</a> aktiviert und bindet dann diese <a href="Zelltyp" title="Zelltyp">Zelltypen</a> dort.<sup id="cite_ref-pmid8170963_1-0" class="reference"><a href="#cite_note-pmid8170963-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid8830793_2-0" class="reference"><a href="#cite_note-pmid8830793-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid2465924_3-0" class="reference"><a href="#cite_note-pmid2465924-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid2923622_4-0" class="reference"><a href="#cite_note-pmid2923622-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> CCL2 wird auch von <a href="Neuron" class="mw-redirect" title="Neuron">Neuronen</a>, <a href="Astrozyt" title="Astrozyt">Astrozyten</a> und <a href="Mikroglia" title="Mikroglia">Mikroglia</a> gebildet. Die <a href="Genexpression" title="Genexpression">Genexpression</a> des CCL2 ist vornehmlich im <a href="Cortex_cerebralis" class="mw-redirect" title="Cortex cerebralis">Cortex cerebralis</a>, im <a href="Globus_pallidus" title="Globus pallidus">Globus pallidus</a>, im <a href="Hippocampus" title="Hippocampus">Hippocampus</a>, in den paraventrikulären und supraoptischen hypothalamischen Nuclei, in der <a href="Substantia_nigra" title="Substantia nigra">Substantia nigra</a>, im <a href="Nucleus_motorius_nervi_facialis" class="mw-redirect" title="Nucleus motorius nervi facialis">Nucleus motorius nervi facialis</a>, in den trigeminalen motorischen und spinalen Nuclei, im gigantozellulären retikulären Nucleus und in den <a href="Purkinje-Zelle" class="mw-redirect" title="Purkinje-Zelle">Purkinje-Zellen</a> des <a href="Cerebellum" class="mw-redirect" title="Cerebellum">Cerebellums</a>.<sup id="cite_ref-Banisadr_5-0" class="reference"><a href="#cite_note-Banisadr-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup>
</p><p>CCL2 wird von den <a href="Rezeptor_(Biochemie)" title="Rezeptor (Biochemie)">Rezeptoren</a> <a href="CCR2" title="CCR2">CCR2</a> und <a href="CCR4" title="CCR4">CCR4</a> gebunden.<sup id="cite_ref-pmid17160712_6-0" class="reference"><a href="#cite_note-pmid17160712-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Nach Stimulation von Zellen mit CCL2 wird die <a href="Genexpression" title="Genexpression">Genexpression</a> von <a href="MCPIP1" title="MCPIP1">MCPIP1</a> induziert.
</p>
<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>
<ol class="references">
<li id="cite_note-pmid8170963-1"><span class="mw-cite-backlink"><a href="#cite_ref-pmid8170963_1-0">↑</a></span> <span class="reference-text">M. W. Carr, S. J. Roth, E. Luther, S. S. Rose, T. A. Springer: <cite style="font-style:italic">Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant</cite>. In: <cite style="font-style:italic"><a href="Proceedings_of_the_National_Academy_of_Sciences" class="mw-redirect" title="Proceedings of the National Academy of Sciences">Proceedings of the National Academy of Sciences</a></cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em">&nbsp;</span>91</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em">&nbsp;</span>9</span>, April 1994, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em">&nbsp;</span>3652–3656</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1073/pnas.91.9.3652">10.1073/pnas.91.9.3652</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/8170963?dopt=Abstract">PMID 8170963</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC43639/">PMC&nbsp;43639</a> (freier Volltext).<span class="Z3988" title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rfr_id=info:sid/de.wikipedia.org:CCL2&amp;rft.atitle=Monocyte+chemoattractant+protein+1+acts+as+a+T-lymphocyte+chemoattractant&amp;rft.au=M.+W.+Carr%2C+S.+J.+Roth%2C+E.+Luther%2C+...&amp;rft.date=1994-04&amp;rft.doi=10.1073%2Fpnas.91.9.3652&amp;rft.genre=journal&amp;rft.issue=9&amp;rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences&amp;rft.pages=3652-3656&amp;rft.pmc=43639&amp;rft.pmid=8170963&amp;rft.volume=91" style="display:none">&nbsp;</span></span>
</li>
<li id="cite_note-pmid8830793-2"><span class="mw-cite-backlink"><a href="#cite_ref-pmid8830793_2-0">↑</a></span> <span class="reference-text">L. L. Xu, M. K. Warren, W. L. Rose, W. Gong, J. M. Wang: <cite style="font-style:italic">Human recombinant monocyte chemotactic protein and other C-C chemokines bind and induce directional migration of dendritic cells in vitro</cite>. In: <cite style="font-style:italic">Journal of Leukocyte Biology</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em">&nbsp;</span>60</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em">&nbsp;</span>3</span>, September 1996, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em">&nbsp;</span>365–371</span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/8830793?dopt=Abstract">PMID 8830793</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rfr_id=info:sid/de.wikipedia.org:CCL2&amp;rft.atitle=Human+recombinant+monocyte+chemotactic+protein+and+other+C-C+chemokines+bind+and+induce+directional+migration+of+dendritic+cells+in+vitro&amp;rft.au=L.+L.+Xu%2C+M.+K.+Warren%2C+W.+L.+Rose%2C+...&amp;rft.date=1996-09&amp;rft.genre=journal&amp;rft.issue=3&amp;rft.jtitle=Journal+of+Leukocyte+Biology&amp;rft.pages=365-371&amp;rft.pmid=8830793&amp;rft.volume=60" style="display:none">&nbsp;</span></span>
</li>
<li id="cite_note-pmid2465924-3"><span class="mw-cite-backlink"><a href="#cite_ref-pmid2465924_3-0">↑</a></span> <span class="reference-text">T. Yoshimura, N. Yuhki, S. K. Moore, E. Appella, M. I. Lerman, E. J. Leonard: <cite style="font-style:italic">Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE</cite>. In: <cite style="font-style:italic">FEBS Letters</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em">&nbsp;</span>244</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em">&nbsp;</span>2</span>, Februar 1989, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em">&nbsp;</span>487–493</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/0014-5793%2889%2980590-3">10.1016/0014-5793(89)80590-3</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/2465924?dopt=Abstract">PMID 2465924</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rfr_id=info:sid/de.wikipedia.org:CCL2&amp;rft.atitle=Human+monocyte+chemoattractant+protein-1+%28MCP-1%29.+Full-length+cDNA+cloning%2C+expression+in+mitogen-stimulated+blood+mononuclear+leukocytes%2C+and+sequence+similarity+to+mouse+competence+gene+JE&amp;rft.au=T.+Yoshimura%2C+N.+Yuhki%2C+S.+K.+Moore%2C+...&amp;rft.date=1989-02&amp;rft.doi=10.1016%2F0014-5793%2889%2980590-3&amp;rft.genre=journal&amp;rft.issue=2&amp;rft.jtitle=FEBS+Letters&amp;rft.pages=487-493&amp;rft.pmid=2465924&amp;rft.volume=244" style="display:none">&nbsp;</span></span>
</li>
<li id="cite_note-pmid2923622-4"><span class="mw-cite-backlink"><a href="#cite_ref-pmid2923622_4-0">↑</a></span> <span class="reference-text">Y. Furutani, H. Nomura, M. Notake, Y. Oyamada, T. Fukui, M. Yamada, C. G. Larsen, J. J. Oppenheim, K. Matsushima: <cite style="font-style:italic">Cloning and sequencing of the cDNA for human monocyte chemotactic and activating factor (MCAF)</cite>. In: <cite style="font-style:italic">Biochemical and Biophysical Research Communications</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em">&nbsp;</span>159</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em">&nbsp;</span>1</span>, Februar 1989, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em">&nbsp;</span>249–255</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/0006-291X%2889%2992430-3">10.1016/0006-291X(89)92430-3</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/2923622?dopt=Abstract">PMID 2923622</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rfr_id=info:sid/de.wikipedia.org:CCL2&amp;rft.atitle=Cloning+and+sequencing+of+the+cDNA+for+human+monocyte+chemotactic+and+activating+factor+%28MCAF%29&amp;rft.au=Y.+Furutani%2C+H.+Nomura%2C+M.+Notake%2C+...&amp;rft.date=1989-02&amp;rft.doi=10.1016%2F0006-291X%2889%2992430-3&amp;rft.genre=journal&amp;rft.issue=1&amp;rft.jtitle=Biochemical+and+Biophysical+Research+Communications&amp;rft.pages=249-255&amp;rft.pmid=2923622&amp;rft.volume=159" style="display:none">&nbsp;</span></span>
</li>
<li id="cite_note-Banisadr-5"><span class="mw-cite-backlink"><a href="#cite_ref-Banisadr_5-0">↑</a></span> <span class="reference-text">G. Banisadr, R. D. Gosselin, P. Mechighel, P. Kitabgi, W. Rostène, S. M. Parsadaniantz: <cite style="font-style:italic">Highly regionalized neuronal expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) in rat brain: evidence for its colocalization with neurotransmitters and neuropeptides</cite>. In: <cite style="font-style:italic">The Journal of Comparative Neurology</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em">&nbsp;</span>489</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em">&nbsp;</span>3</span>, August 2005, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em">&nbsp;</span>275–292</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1002/cne.20598">10.1002/cne.20598</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/16025454?dopt=Abstract">PMID 16025454</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rfr_id=info:sid/de.wikipedia.org:CCL2&amp;rft.atitle=Highly+regionalized+neuronal+expression+of+monocyte+chemoattractant+protein-1+%28MCP-1%2FCCL2%29+in+rat+brain%3A+evidence+for+its+colocalization+with+neurotransmitters+and+neuropeptides&amp;rft.au=G.+Banisadr%2C+R.+D.+Gosselin%2C+P.+Mechighel%2C+...&amp;rft.date=2005-08&amp;rft.doi=10.1002%2Fcne.20598&amp;rft.genre=journal&amp;rft.issue=3&amp;rft.jtitle=The+Journal+of+Comparative+Neurology&amp;rft.pages=275-292&amp;rft.pmid=16025454&amp;rft.volume=489" style="display:none">&nbsp;</span></span>
</li>
<li id="cite_note-pmid17160712-6"><span class="mw-cite-backlink"><a href="#cite_ref-pmid17160712_6-0">↑</a></span> <span class="reference-text">M. J. Craig, R. D. Loberg: <cite style="font-style:italic">CCL2 (Monocyte Chemoattractant Protein-1) in cancer bone metastases</cite>. In: <cite style="font-style:italic">Cancer Metastasis Reviews</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em">&nbsp;</span>25</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em">&nbsp;</span>4</span>, Dezember 2006, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em">&nbsp;</span>611–9</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1007/s10555-006-9027-x">10.1007/s10555-006-9027-x</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/17160712?dopt=Abstract">PMID 17160712</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rfr_id=info:sid/de.wikipedia.org:CCL2&amp;rft.atitle=CCL2+%28Monocyte+Chemoattractant+Protein-1%29+in+cancer+bone+metastases&amp;rft.au=M.+J.+Craig%2C+R.+D.+Loberg&amp;rft.date=2006-12&amp;rft.doi=10.1007%2Fs10555-006-9027-x&amp;rft.genre=journal&amp;rft.issue=4&amp;rft.jtitle=Cancer+Metastasis+Reviews&amp;rft.pages=611-9&amp;rft.pmid=17160712&amp;rft.volume=25" style="display:none">&nbsp;</span></span>
</li>
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